Queen Ester

Though not in the spiritual realm, Esther was one of the greatest, but unheralded leaders of a champion work for God. A plot by Haman in the land of Persia would have slaughtered all Jews residing there. Haman was the second in command to the king.  It was this woman who brought about the safe discharge of her people.  She led her handmaidens in a fast, which delivered ALL the people of God from death in the book of Esther. Esther was the vehicle upon which deliverance for the Jews arrived. Her uncle Mordecai informed her of this plot.

Esther 4: 14: …and who knoweth whether thou art come to the kingdom for such a time as this? He said.
Esther responded

Esther4: 16: Go, gather together all the Jews that are present in Shushan, and fast ye for me, and neither eat nor drink three days, night or day: I also and my maidens will fast likewise; and so will I go in unto the king, which is not according to the law: and if I perish, I perish.

The scripture goes on to say that Mordecai, her uncle did as Esther commanded him. This was a case of a man submitting to a woman.   It was the plan and command of Queen Esther that brought about deliverance.  Esther 9:25, 29: But when Esther came before the king, the King commanded by letters that the  wicked devices [Haman] devised against the Jews, should return upon his own head. He and his sons were to  be hanged on the gallows.

29: Then Esther the queen, the daughter of Abihail, and Mordecai the Jew, wrote with all authority, to confirm this second letter of Purim.

We find many examples of the Lord using women in the Old Testament.  The Old Testament was written as an example to us, so we can expect to find women in similar roles as time continues.  We see that women were mightily used of our Lord and God.